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Disopyramide in Hypertrophic Cardiomyopathy

Colchicine for Recurrent Pericarditis

The most troublesome complication of acute pericarditis is recurrent episodes of pericardial inflammation, occurring in 15% to 32% of cases.

The cause of the recurrence is usually unknown, although in some cases it may be traced to viral infection or may be a consequence of coronary artery bypass grafting. The optimal method for prevention has not been fully established; accepted modalities include nonsteroidal anti-inflammatory drugs, corticosteroids, immunosuppressive agents, and pericardiectomy.

Based on the proven efficacy of colchicine therapy for familial Mediterranean fever (recurrent polyserositis), several small studies have used colchicine successfully to prevent recurrence of acute pericarditis after failure of conventional treatment.

In the largest multicenter international study - 51 patients were treated with colchicine to prevent further relapses and were followed up for up to 10 years.

The evidence for the efficacy and safety of colchicine for the prevention of recurrent episodes of pericarditis shows that colchicine may be an extremely promising adjunct to conventional treatment and may ultimately serve as the initial mode of treatment, especially in idiopathic cases.

Circulation 1998 Jun 2;97(21):2183-5

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