Dr. Fredric E. Wondisford is Professor, Chairman of Medicine and Chancellor Scholar, Rutgers-Robert Wood Johnson School of Medicine. Prior to this appointment, he was Professor of Medicine, Pediatrics and Physiology and Director of the Metabolism Division and Diabetes Institute at Johns Hopkins University School of Medicine. Dr. Wondisford has been continuously funded by the NIH since 1990 and has scientifically mentored 64 trainees, and 41 have gone on to independent academic research careers. Dr Wondisford’s laboratory has two main research interests: regulation of gene expression by nuclear thyroid hormone receptors and control of hepatic glucose production (HGP) in health and disease.
Dr. Sally Radovick is a specialist in growth and development and pubertal disorders in children. Her research has focused on the developmental regulation of hypothalamic-pituitary function. Her laboratory has elucidated some of the factors that control Gonadotropic Releasing Hormone (GnRH) gene expression and the intracellular signaling pathways within the GnRH neuron. The laboratory uses neuronal cell cultures and genetically engineered mice as models for human disease. Dr. Radovick's laboratory has demonstrated that the GnRH gene is the target of growth factor and nuclear hormone signaling pathways, which link nutrition and growth with pubertal development and reproduction. Another major area of her research has been to characterize the transcription factors important for normal pituitary development. Her initial studies provided the first description in man of the genetic mechanism for combined pituitary hormone deficiency. She has been NIH funded in conducting biomedical research and mentoring students and fellows for over 25 years, mentoring over 50 graduate students, postdoctoral fellows and junior faculty.